Felix Nicolae Sima

Affiliation and official address:

Laser-Surface-Plasma Interactions Laboratory, Laser Department,

National Institute for Lasers, Plasma, and Radiation Physics (INFLPR),

Institute of Atomic Physics, 409 Atomistilor Street,

P.O. Box MG-36 RO-77125, Magurele, Bucharest V, Romania,

Phone: (40)-(21) 457 44 91,

Fax: (40)-(21) 457 42 43, 457 44 67,

felix.sima@inflpr.ro,

http://lspi.inflpr.ro/ 

Date and place of birth: October 1^st, 1978; Urziceni, Ialomita, Romania ,

Nationality: Romanian

Education:

• July 2014 - July 2015 : Postdoctoral Program (Japanese Society for Promotion of Science - JSPS ) ,  JSPS and RIKEN Center of Advanced Photonics, principal subject : "  Advanced laser technology for creation of functional materials" .
• May 2012 - May 2013  : Postdoctoral Program (European Social Funding - Operational Sectorial Program for Human Resource Development) , National Institute of Lasers, Plasma and Radiation Physics and Institute of Biochemistry of Romanian Academy, principal subject :  " Biomaterials, nanostructures and pharmacophores/ Laser applications in nanostructures for controlled drug administration, implants and tissue reconstruction "
• June 2007 - October 2011 : PhD student, bilateral, Supervisors : Prof. Ion N. Mihailescu, Karine Anselme,  Institute des Sciences de Materiaux, Haute Alsace University, Mulhouse, France  and Faculty of Physics, University of Bucharest, thesis : " Synthèse de nanostructures hybrides biomimétiques (phosphates de calcium + protéines par techniques laser avancées : études structurales, biochimiques et biologiques "
• February 2004 - October 2011: PhD student, Supervisor Prof. Dr. Ion N. Mihailescu, Faculty of Physics, University of Bucharest, thesis : " Biomaterial thin nanostructured films obtained by pulsed laser technologies for biomedical applications "
• October 2004 - March 2005  : ERASMUS programme scholarship, Institut National des Sciences Appliquees (INSA) , Strasbourg , France, thesis :" Structural characterization of PZT ceramics "
• October 2003 - June 2005 : M. Sc. from the Faculty of Physics - University of Bucharest, Department of Solid Physics; Master thesis: “Different methods of structural investigation of PZT type ceramics”;
• October 2001 - September 2002 : Special Auditor Student in Radiation Physics, Hirosaki University, Japan
• October 1998 - June 2003 : Graduated from the Hyperion University of Bucharest - Faculty of Physics after majoring in Biophysics; graduation thesis: “Advanced piezoceramics materials with applications in medicine”;

Specialization:

-          main field: Solid Physics, Laser Physics;

-          other fields: Biophysics, plasma and laser theory;

-          current research interests: Deposition and modification of thin solid structures by high intensity laser irradiation; biomaterials; optoelectronics and sensors; Surface studies with lasers; surface processing; deposition and modification of thin solid structures by high intensity laser irradiation;

Foreign languages: English, French, Japanese

Career/Employment:

• July 2014  - Present  :  Scientific Researcher 2nd degree  , National Institute for Lasers, Plasma and Radiation Physics, Laser Department, Bucharest-Magurele, Romania; responsibilities : surface and volume engineering with pulsed lasers, laser material interaction and processing, femtosecond and nanosecond laser processing, chemical etching, two photon polymerization, microfluidics, biomimetics, 2D and 3D microscopies, thin films and coatings, IR microspectroscopy 
• July 2015 - July 2018 : Visiting Scientist , RIKEN-SIOM Joint Research Unit, RIKEN Center for Advanced Photonics, Wako, Saitama, JAPAN, responsibilities : femtosecond laser assisted etching, two-photon laser processing of polymers, scanning electron microscopy, profilometry, time lapse imagining of cancer cells, hybrid laser processing of transparent materials, microfluidics
• January 2011- July 2014  : Scientific Researcher 3rd degree  , National Institute for Lasers, Plasma and Radiation Physics, Laser Department, Bucharest-Magurele, Romania; responsibilities : laser ablation, pulsed laser deposition, matrix assisted pulsed laser evaporation, laser-material interactions, surface processing, biomimetics, nano-bio interface, biosensing, immunoassays, cell adhesion, polymer thin films, infrared spectroscopy
• June 2006 - January 2011: Scientific Researcher, National Institute for Lasers, Plasma and Radiation Physics, Laser Department, Bucharest-Magurele, Romania; responsibilities : deposition and modification of thin solid structures by laser irradiation; biomaterials; surface engineering; deposition and modification of thin films by laser irradiation
• May 2005 - June 2006: Research Assistant Scientist, National Institute for Lasers, Plasma and Radiation Physics, Laser Department, Bucharest-Magurele, Romania; responsibilities : surface modifications with lasers; surface  and material processing; deposition of thinn solid structures by excimer laser irradiation
• December 2003 - May 2005: Research Assistant Scientist, National Institute for Materials Physics, Oxides Laboratory, Bucharest-Magurele, Romania; responsibilities : doping effect on the piezoelectric properties of PZT type materials, physico-chemical characterization, transducer properties

 Scholarships:

• 2014 - Postdoctoral Scholarship (Japanese Society for Promotion of Science -JSPS)
• 2012- Postdoctoral Scholarship (European Social Funding - Operational Sectorial Program for Human Resource Development)
• 2007- Bourse du gouvernement francais (BGF) – French government scholarship, Institut de Sciences des Materiaux (IS2M), Mulhouse, France;
• 2004-Erasmus program scholarship, Institut National des Sciences Appliquees (INSA), Strasbourg, France;
• 2001-Certificate of Enrolment, Association of International Education, Japan (AIEJ) Short-term Student Exchange Promotion Program (inbound) Scholarship;

Awards:

• 2013 -  First Prize, Award “Best Innovative Ideas for a Research Project”  with the oral communication “Biomimetic organic composite materials assembled in multilayer configurations by a new combinatorial laser method” at the International Conference Materials in Medicine – MiMe, 8-11 October, 2013, Faenza, Italy
• 2012 – Third prize Roger Kelly Award “Hybrid biomimetic multilayers obtained by pulsed laser deposition methods”, Poster communication at School on Lasers in Materials Science – SLIMS, 8-15 July 2012, Venice, Italy
• 2010 – First prize Award for Poster presentation “Immunoglobulin nanostructures obtained by MAPLE for biosensor applications” at NATO Advanced Study Institute Technological Innovations in Detection and Sensing of Chem.-Bio-Radiological-Nuclear and Ecological Terrorism, June 07-17, Chisinau, Moldova
• 2010 – Second Prize Award for Poster presentation “Protein based synthesized by laser assisted methods: physico-chemical characterization and immunofluorescence studies” at NATO – Advanced Study Institute “Nanotechnological Basis for Advanced Sensors”, Sozopol, Bulgaria.
• 2009 - Award for the outstanding scientific poster presentation at “New challenges in heat treatment and surface engineering” Conference, Cavtat, Croatia, June, 2009.
• 2008 - Best poster prize „Bioglass-polymer thin coatings obtained by pulsed laser technologies for a new generation of orthopaedic implants”, 15^th International School on Condensed Matter Physics, Varna, Bulgaria;
• 2007 – Poster award winner at NATO – Advanced Study Institute “Functionalized Nanoscale Materials, Devices, and Systems for Chem.-Bio Sensors, Photonics and Energy Generation and Storage, Sinaia, Romania, June 4-15;
• 2001-Certificate of School Grade – Japanese language, Hyperion Academic Society, Bucharest, Romania;

Director of National and bilateral Grants:

• Bilateral project - cooperation- Integrated Action “Capacities” program Romania – France call PN-II-CT-RO-FR-2014-2, organised by UEFISCDI and PHC with IS2M (Mulhouse, France, Dr. Camelia Ghimbeu) “Synthèse et fonctionnalisation de matériaux nanostructurés carbonés par des techniques laser” (“Sinteza si functionalizarea laser de materiale nanostructurate pe baza de carbon”) (2015-2016);
• Bilateral project through “Capacities” program between Romania (UEFISCDI) and Japan (JSPS), RIKEN-SIOM Joint Research Unit, RIKEN Center for Advanced Photonics, RIKEN, 2-1 Hirosawa, Wako, Saitama, Japan (2014-2015);
• Postdoctoral Grant 2011-2013: LASER INDUCED CLEAN TRANSFER OF PROTEIN NANOSTRUCTURES FOR BIOMIMETIC APPLICTIONS  - PD 101 / 01.2012; PN-II-RU-PD-2011-3-0147;
• Postdoctoral scholarship 2012-2013: “Thin coatings of biodegradable polymers and proteins/drugs obtained by pulsed lasers for pharmaceutical and regenerative medicine applications” within the programme "Cellular and molecular biotechnologies for medical applications"

Collaboration on Research Grants

Bilateral Grants:

• Team member within the program with France: Brancusi Project 14775SL, 2007-2008, Title: Réalisation par techniques de dépôt laser avancées (PLD, MAPLE, MAPLE DW) de structures multi-couches biomimétiques pour la régénération des tissus osseux et cartilagineux.

International Grants:

• Team member in EUREKA Project E!3033, 2006-2008, BIONANOCOMPOSIT
• Team member in Ministry of Education and Research Grants on topics such as nanomaterials processing, thin films, laser and plasma physics, solid state physics.

Competence areas:

- working with UV KrF*excimer laser sources (λ = 248 nm, pulse duration 7 ns)

- pulsed laser deposition and reactive PLD of HA, OCP, TiN, AlN, LiNbO₃, ZnO, Al₂O₃, polymers, Cr oxides etc…

- investigations by scanning electron microscopy (SEM), X ray diffraction (XRD) including grazing incidence X ray diffraction (GIXRD), optical microscopy, nanoindentation.

Relevant book chapters:

1. Sima F., Mihailescu I. N., “Biomimetic assemblies by matrix-assisted pulsed laser evaporation” in “Laser Technology in Biomimetics”, Volker Schmidt, Maria R. Belegratis (eds.), Springer Series in Biological and Medical Physics, Biomedical Engineering, ISBN 978-3-642-41340-7, uncorrected proof, Springer International Publishing Switzerland, p. 1-26, 2014;
2. Mihailescu I. N., Bigi A., Gyorgy E., Ristoscu C., Sima F., Toksoy Oner E., Chapter 11, “Biomaterial Thin Films by Soft Pulsed Laser Technologies for Biomedical Applications” in “Lasers in Materials Science”, P. Ossi et al. (eds.), Springer Series in Materials Science 191, DOI: 10.1007/978-3-319-02898-9_11, corrected proof, Springer International Publishing Switzerland, p. 1-24, 2014;
3. Capuccini C., Boanini E., Bigi A., Gazzano M., Sima F., Axente E., Mihailescu I. N.  “Strontium-Substituted Hydroxyapatite Thin Films Grown by Pulsed Laser Deposition” in “Functionalized Nanoscale Materials, Devices, & Systems”, Edited by A. Vaseashta, and I. N. Mihailescu, SPRINGER SCIENCE + BUSINESS MEDIA B.V., p. 389-398, 2008;

1. Sima F., Davidson PM, Dentzer J, Gadiou R, Pauthe E, Gallet O, Mihailescu IN, Anselme K, “Inorganic-organic thin implant coatings deposited by lasers”, ACS Applied Materials & Interfaces, 7(1):911-920, 2015;
2. Sima F., Wu D., Xu J., Midorikawa, K., Sugioka K., “Ship-in-a-bottle integration by hybrid femtosecond laser technology for fabrication of true 3D biochips”, Proceedings of the SPIE, Volume 9350, id. 93500F-8, 2015;
3. Ghimbeu C.M., Sopronyi M., Sima F., Delmotte L., Vaulot C., Zlotea C., Paul-Boncour V., Le Meins J.M., “One-pot laser-assisted synthesis of porous carbon with embedded magnetic cobalt nanoparticles”, Nanoscale, 7 (22), 10111-10122, 2015;
4. Boanini E., Torricelli P., Sima F., Axente E., Fini M., Mihailescu IN., Bigi A., “Strontium and zoledronate hydroxyapatites graded composite coatings for bone prostheses”, Journal of Colloid and Interface Science, 448:1-7, 2015;
5. Matei Ghimbeu C., Soprony M., Sima F., Vaulot C., Vidal L., Le Meins J-M., Delmotte L., “Light-assisted evaporation induced self-assembly”: an efficient approach toward ordered carbon materials, RSC Advances, 5, 2861-2868, 2015;
6. Sima F., Axente E., Iordache I., Luculescu C., Gallet O., Anselme K., Mihailescu I.N., Combinatorial Matrix Assisted Pulsed Laser Evaporation of a biodegradable polymer and fibronectin for protein immobilization and controlled release, Applied Surface Science, 306, 75, 2014;
7. Axente E., Sima F., Sima L.E., Erginer M., Eroglu M.S., Serban N., Ristoscu C., Petrescu, S.M. Toksoy Oner E., Mihailescu I.N., Combinatorial MAPLE gradient thin film assemblies signalling to human osteoblasts, Biofabrication, 6 035010, 2014;
8. Sima F., Axente E., Sima L.E., Tuyel U., Eroglu M.S., Serban N., Ristoscu C., Petrescu S.M., Toksoy Oner E., Mihailescu I.N., "Combinatorial Matrix-Assisted Pulsed Laser Evaporation: single-step synthesis of biopolymer compositional gradient thin film assemblies", Applied Physics Letters,101, 233705, 2012;
9. Sima F., Davidson P., Pauthe E., Sima L.E., Gallet O., Mihailescu I.N., Anselme K. Fibronectin layers obtained by matrix assisted pulsed laser evaporation from saline buffer based cryogenic targets, Acta Biomaterialia, 7 (10), 3780-3788, 2011;
10. Sima F., Davidson P., Pauthe E., Gallet O., Anselme K., Mihailescu I.N. Thin films of vitronectin transferred by MAPLE, Applied Physics A, A 105, 611–617, 2011;
11. Sima F., Mutlu E.C., Eroglu M.S., Sima L.E., Serban N, Ristoscu C, Petrescu S.M., Toksoy Oner E., Mihailescu I.N., Levan Nanostructured Thin Films by MAPLE Assembling, Biomacromolecules, 12, 2251, 2011;
12. Sima F., Axente E., Ristoscu C., Mihailescu I.N., Kononenko T.V, Nagovitsin I.A., Chudinova G., Konov V.I., Socol M, Enculescu I, Sima L.E., Petrescu S.M., Tailoring immobilization of immunoglobulin by excimer laser for biosensor applications, Journal of Biomedical Materials Research-A, 96A (2), 384 - 394, 2011;
13. Sima F., Ristoscu C., Caiteanu D., Mihailescu C.N., Stefan N., Mihailescu I.N., Prodan G., Ciupina V., Palcevskis E., Krastins J., Sima L.E., Petrescu S.M. Biocompatibility and bioactivity enhancement of Ce stabilized ZrO2 doped HA coatings by controlled porosity change of Al2O3 substrates, J Biomed Mater Res B, 96B (2),  218-224, 2011;
14. Smausz T., Megyeri G., Kékesi R., Vass C., György E., Sima F., Mihailescu I. N., Hopp B., Comparative study on Pulsed Laser Deposition and Matrix Assisted Pulsed Laser Evaporation of urease thin films, , Thin Solid Films, 517, 15, 4299-4302, 2009;
15. Sima F., Ristoscu C., Popescu A., Mihailescu I.N., Kononenko T., Simon S., Radu T., Ponta O., Mustata R., Sima L.E., Petrescu S.M.,Bioglass –polymer thin coatings obtained by MAPLE for a new generation of implants, Journal of Optoelectronics and Advanced Materials, Topical Issue: Interfaces, Thin Solid Films and Biomolecular Layers, p. 1170 – 1174, 11, 9, 2009;
16. Sima F., Ristoscu C., Stefan N., Dorcioman G., Mihailescu I.N., Sima L.E., Petrescu S.M., Palcevskis E., Krastins J., Zalite I., Shallow hydroxyapatite coatings pulsed laser deposited onto Al2O3 substrates with controlled porosity: correlation of morphological characteristics with in vitro testing results, Applied Surface Science, 255, 10, 5312-5317, 2009;
17. Bigi A., Boanini E., Capuccini C., Fini M., Mihailescu I.N., Ristoscu C., Sima F., Torricelli P., Biofunctional alendronate–Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation, Biomaterials, 30, 31, 6168-6177, 2009;
18. Capuccini C., Torricelli P., Sima F., Boanini E., Ristoscu C., Bracci B., Socol G., Fini M., Mihailescu I.N., Bigi A., Strontium-substituted hydroxyapatite coatings synthesized by pulsed-laser deposition: In vitro osteoblast and osteoclast response, Acta Biomaterialia, 4, 6, 1885-1893, 2008;
19. Sima F., Socol G., Axente E., Mihailescu I.N., Zdrentu L., Petrescu S.M., Mayer I., Biocompatible and bioactive coatings of Mn2+-doped β-tricalcium phosphate synthesized by pulsed laser deposition, Applied Surface Science, 254, 4, 1155-1159, 2007;

Patent:

Inventor(s): CHIRIAC A, DUTA L, IANCULESCU A, MIHAILESCU I, MIROIU M, PETRESCU S, POEATA I, POPESCU A, SIMA F, SOCOL G, STAN G, “MESH MADE OF Ti WITH BIOFUNCTIONALIZED SURFACE WITH NANOSTRUCTURED HYDROXYAPATITE THIN FILMS FOR CRANIOPLASTY”; Patent Number: RO128190-A2; Patent Assignee: UNIV MEDICINA SI FARM GR T POPA;

Communications:

Invited:

1. Femto 16-17 March, 2015, Mauterndorf, Austria  F. Sima, D. Wu, J. Xu, K. Midorikawa, K. Sugioka “Hybrid subtractive and additive femtosecond laser micro-machining for highly functional biochip fabrication”, Invited

2.RSBMB Anniversary Conference – 25 years of promoting molecular life sciences 7-18 September, 2015, Bucharest, Romania F. Sima, I.N. Mihailescu “Bioresponsive material surfaces fabricated by innovative laser approaches”, Invited

Oral communications and representative posters

1. Laser Advanced Material Processing - LAMP 26-29 May, 2015, Kitakyushu, Fukuoka, Japan F. Sima, D. Wu, J. Xu, K. Midorikawa, K. Sugioka “Hybrid femtosecond laser micro-integration of polymeric patterns inside glass channels for cell manipulation”, Oral communication

2.Photonics West 7-12 February, 2015, San Francisco, USA F. Sima, D. Wu, J. Xu, K. Midorikawa, K. Sugioka “Ship-in-a-bottle integration by hybrid femtosecond laser technology for fabrication of true 3D biochips”, Oral communication

3.IEEJ Topical Meeting Laser Processing & Advanced Technology 6 March, 2015, Hirosaki, Japan F. Sima, D. Wu, J. Xu, K. Midorikawa, K. Sugioka “Hybrid subtractive - additive femtosecond laser processing for “ship-in-a-bottle” integration of 3D polymer patterns inside glass micro-channels for single cell monitoring”, Oral communication

4.Materials in Medicine - MiMe 8-11 October, 2013, Faenza, Italy F. Sima, E. Axente, L.E. Sima, E. Pauthe, O. Gallet, K. Anselme, I.N. Mihailescu “Biomimetic organic composite materials assembled in multilayer configurations by a new combinatorial laser method”, Oral communication, Award “Best Innovative Ideas for a Research Project”

5.E-MRS Fall Meeting 16-20 September, 2013, Warsaw, Poland F. Sima, E. Axente, L.E. Sima, E. Toksoy Oner, I.N. Mihailescu “Combinatorial Matrix-Assisted Pulsed Laser Evaporation of Variable Composition Polymeric Materials”, Oral communication

6.Modern Laser Applications - INDLAS 20-24 May, 2013, Bran, Romania F. Sima, E. Axente, L.E. Sima, E. Pauthe, O. Gallet, E. Toksoy Oner, K. Anselme, I.N. Mihailescu “Biomimetic multilayered structures by matrix-assisted pulsed laser evaporation”, Oral communication

7.School on Lasers in Materials Science – SLIMS 8-15 July 2012, Venice, Italy F. Sima, P. Davidson, J. Dentzer, R. Gadiou, E. Pauthe, O. Gallet, K. Anselme, I. N. Mihailescu “Hybrid biomimetic multilayers obtained by pulsed laser deposition methods”, Poster and oral communication, poster award

8.Advanced Laser Technologies 2011, 3-8 September, 2011, Golden Sands, Bulgaria, F. Sima, P. Davidson, E. Pauthe, O. Gallet, K. Anselme, C. Ristoscu, I.N. Mihailescu “Protein layers transferred by MAPLE: structural, biochemical and biologica characterization”, Oral communication;

9.EMRS Spring Meeting Strasbourg, France, 7-11 June 2010 F. Sima, P. Davidson, E. Pauthe, O. Gallet, K. Anselme, I. N. Mihailescu “Fibronectin and vitronectin immobilization by MAPLE on HA nanolayers: a synergetic biointerface for medical implants”, Oral communication;

10.Séminaire Doctorant, 22 April 2010, IS2M, amphi1, University Haute Alsace, Mulhouse, France F. Sima, P. Davidson, E. Pauthe, O. Gallet, I.N. Mihailescu, K. Anselme “Synthèse de nanostructures hybrids biomimétiques (phosphates de calcium + protéines) par techniques laser avancées : études structurales, biochimiques et biologiques”, Oral communication;

11.Workshop EUREKA « BIONANOCOMPOSIT » 2009 Strasbourg, France, 19-20 November 2009. F. Sima, G. Dorcioman, C. Ristoscu, I.N. Mihailescu, M. Mateescu, K. Anselme, E. Pauthe, O. Gallet “Extracellular matrix protein immobilization by pulsed laser assisted evaporation”, Oral communication;

12.PHOTONICS 2009, Delphi, Greece, 7-9 October 2009 F. Sima, P. Davidson, E. Pauthe, O. Gallet, K. Anselme, I. N. Mihailescu “Vitronectin nanostructures immobilized by laser techniques for osteoblast adhesion improvement”, Oral communication;

13.ROMOPTO 2009, Sibiu, Romania, 31 August– 3 September, 2009 F. Sima, E. Axente, C. Ristoscu, C. N. Mihailescu, I.N. Mihailescu, K. Anselme, L.E. Sima, S. M. Petrescu, E. Pauthe, O. Gallet “Protein immobilization by pulsed laser techniques to modify cell/biomaterial interactions”, Oral communication;

14.BIOMATERIALEN 2009, Rostock, Germania, 13-15 May 2009 F. Sima, F. Admane, J.Leroy-Dudal, K. Anselme, E. Pauthe, I. N. Mihailescu, O. Gallet “Coatings of vitronectin by adsorption or laser deposition onto dense or thin layer hydroxyapatite supports”, Poster presentation;

15.BIOPRINTING AND BIOFABRICATION 2009, Bordeaux, France, 6-9 July 2009 F. Sima, E. Axente, P. Davidson, E. Pauthe, O. Gallet, I. N. Mihailescu, K. Anselme “MAPLE immobilization of extracellular matrix proteins onto hydroxyapatite nanostructured layers: immunodetection and cell adhesion”, Poster presentation;