Valentina Grumezescu

                                                                                               

Affiliation and official address: 

“Laser-Surface-Plasma Interactions” Laboratory, Lasers Department

National Institute for Lasers, Plasma and Radiation Physics - INFLPR

P.O. Box MG-36 RO-77125

Magurele, Bucharest, Romania

   Phone: 004 021 457 44 91 

valentina.grumezescu@inflpr.ro

http://lspi.inflpr.ro/ 

Date and place of birth: October 29th, 1988; Bucharest, Romania.

Nationality: Romanian

Education:

2013 - presentPhD student at Politehnica University of Bucharest, Doctoral School Applied Chemistry and Materials Science; Department of Science and Engineering of Oxidic Materials and Nanomaterials

2011 - 2013MSc. Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science; Department of Science and Engineering of Oxidic Materials and Nanomaterials, Master: Micro and Nanomaterials, Master thesis: "Ferromagnetic Biomaterials".

2007 - 2011BSc. Politehnica University of Bucharest, Faculty of Applied Chemistry and Materials Science.

Professional Activity:

January 2014present: Scientific Researcher at National Institute for Lasers, Plasma and Radiation Physics.

April 2013December 2013: Research Assistant at National Institute for Lasers, Plasma and Radiation Physics.

October 2012 - March 2013: Junior Research Assistant at National Institute for Lasers, Plasma and Radiation Physics.

January 2011present: Assistant Editor - Biointerface Research in Applied Chemistry

January 2011present: Assistant Editor - Letters in Applied NanoBioScience

Awards:

 

Publications:

2017

1. Grumezescu, V.; Holban, A.M.; Sima, L.E.; Chiritoiu, M.B.; Chiritoiu, G.N.; Grumezescu, A.M.; Ivan, L.; Safciuc, F.; Antohe, F.; Florica, C.; Luculescu, C.R.; Chifiriuc, M.C.; Socol, G. Laser deposition of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) - lysozyme microspheres based coatings with anti-microbial properties. INTERNATIONAL JOURNAL OF PHARMACEUTICS 521 (1-2) 184-195 2017 . IF2016 =3.649

2. Curutiu, C., Grumezescu, V., Chifiriuc, M.C., Huang, K.-S., Iordache, F., Lin, Y.-M., Holban, A.M. Nanostructured approaches for the targeted delivery of antibiotics in difficult infections. CURRENT ORGANIC CHEMISTRY Volume 21(1) 45-52 2017. IF2016 = 1.924

3. Rașoga, O., Sima, L., Chirițoiu, M., Popescu-Pelin, G., Fufă, O., Grumezescu, V., Socol, M., Stănculescu, A., Zgură, I., Socol, G. Biocomposite coatings based on Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/calcium phosphates obtained by MAPLE for bone tissue engineering. APPLIED SURFACE SCIENCE 417, 204-212, 2017. IF2016 = 3.387

2016

1. Oprea, A.E., Pandel, L.M., Dumitrescu, A.M., Andronescu, E., Grumezescu, V., Chifiriuc, M.C., Mogoantă, L., BǍlşeanu, T.-A., Mogoşanu, G.D., Socol, G., Grumezescu, A.M., Iordache, F., Maniu, H., Chirea, M., Holban, A.M. Bioactive ZnO coatings deposited by MAPLE - An appropriate strategy to produce efficient anti-biofilm surfaces, Molecules 21(2), 220, 2016. IF = 2.861

2. Bjelajac, A., Petrovic, R., Socol, G., Mihailescu, I.N., Enculescu, M., Grumezescu, V., Pavlovic, V., Janackovic, D. CdS quantum dots sensitized TiO2 nanotubes by matrix assisted pulsed laser evaporation method. Ceramics International, 42(7), 9011-9017, 2016. IF = 2.986

3. Rădulescu, D., Voicu, G., Oprea, A.E., Andronescu, E., Grumezescu, V., Holban, A.M., Vasile, B.S., Surdu, A.V., Grumezescu, A.M., Socol, G., Mogoantă, L., Mogoşanu, G.D., Balaure, P.C., RǍdulescu, R., Chifiriuc, M.C. Mesoporous silica coatings for cephalosporin active release at the bone-implant interface. Applied Surface Science, 374, 165-171, 2016. IF = 3.387

4. Rădulescu, D., Grumezescu, V., Andronescu, E., Holban, A.M., Grumezescu, A.M., Socol, G., Oprea, A.E., Rădulescu, M., Surdu, A., Trusca, R., Rădulescu, R., Chifiriuc, M.C., Stan, M.S., Constanda, S., Dinischiotu, A. Biocompatible cephalosporin-hydroxyapatite-poly(lactic-co-glycolic acid)-coatings fabricated by MAPLE technique for the prevention of bone implant associated infections. Applied Surface Science, 374, 387-396, 2016. IF = 3.387

5. Stan, M.S., Constanda, S., Grumezescu, V., Andronescu, E., Ene, A.M., Holban, A.M., Vasile, B.S., Mogoantă, L., Bălşeanu, T.-A., Mogoşanu, G.D., Socol, G., Grumezescu, A.M., Dinischiotu, A., Lazar, V., Chifiriuc, M.C. Thin coatings based on ZnO@C18-usnic acid nanoparticles prepared by MAPLE inhibit the development of Salmonella enterica early biofilm growth. Applied Surface Science, 374, 318-325, 2016. IF = 3.387

6. Socol, M., Preda, N., Rasoga, O., Breazu, C., Stavarache, I., Stanculescu, F., Socol, G., Gherendi, F., Grumezescu, V., Popescu-Pelin, G., Girtan, M., Stefan, N. Flexible heterostructures based on metal phthalocyanines thin films obtained by MAPLE. Applied Surface Science, 374, 403-410, 2016. IF = 3.387

7.  Holban A.M., Vlad M., Grumezescu V., Ficai A., Bleotu C., Aldea (Pitica) I.M., Grumezescu A.M., Andronescu E. “Impact Of Alginate On The Biocompatibility Of Magnetite Nanoparticles Utilized For Drug Delivery” U.P.B. Sci. Bull., Series B, 78(4), (2016), ISSN 1454-2331.

2015

1. Holban,  A.M., Andronescu, E., Grumezescu, V., Oprea, A.E., Grumezescu, A.M., Socol, G., Chifiriuc, M.C., Lazar, V., Iordache, F. Carvone functionalized iron oxide nanostructures thin films prepared by MAPLE for improved resistance to microbial colonization. Journal of Sol-Gel Science and Technology, 73(3), 605-611, 2015. IF = 1.473

2. Grumezescu, A.M., Andronescu, E., Oprea, A.E., Holban, A.M., Socol, G., Grumezescu, V., Chifiriuc, M.C., Iordache, F., Maniu, H. MAPLE fabricated magnetite@Melissa officinalis and poly lactic acid – chitosan coated surfaces with anti-staphylococcal properties. Journal of Sol-Gel Science and Technology, 73(3), 612-619, 2015. IF = 1.473

3. Grumezescu V., Andronescu E., Holban A.M., Mogoantă L., Mogoșanu G.D., Grumezescu A.M., Stănculescu A., Socol G., Iordache F., Maniu H., Chifiriuc C.M. MAPLE fabrication of thin films based on kanamycin functionalized magnetite nanoparticles with anti-pathogenic properties.  Applied Surface Science, 336, 188-195, 2015. IF = 3.150

4. Grumezescu V.; Andronescu E.; Holban A.M.; Socol G.; Grumezescu A.; Ficai A.; Lazar V.; Chifiriuc C.M.; Trusca R.; Iordache F. Fabrication and characterization of functionalized surfaces with 3-amino propyltrimethoxysilane films for anti-infective therapy applications. Applied Surface Science, 336, 401-406, 2015. IF = 3.150

5. Iordache F.; Grumezescu V.; Grumezescu A.; Curuțiu C.; Dițu L.M.; Socol G.; Ficai A.; Trusca R.; Holban A.M. Gamma-cyclodextrin/usnic acid thin film fabricated by MAPLE for improving the resistance of medical surfaces to Staphylococcus aureus colonization. Applied Surface Science, 336, 407-4121, 2015. IF = 3.150

6. Iordache F., Oprea A.E., Grumezescu V., Andronescu E., Socol G., Grumezescu A.M., Popa M., Mogoșanu G.D., Holban A.M., Maniu H. Poly(lactic-co-glycolic) acid/chitosan microsphere thin films functionalized with Cinnamomi aetheroleum and magnetite nanoparticles for preventing the microbial colonization of medical surfaces. Journal of Sol-Gel Science and Technology, 73(3), 679-686, 2015. IF = 1.473

2014

1.  Grumezescu A.M., Ghitulica, C.D., Voicu, G.,  Huang, K.S.,  Yang, C.H., Ficai, A., Vasile, B.S., Grumezescu, V., Bleotu, C., Chifiriuc, C.M. New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections. International Journal of Pharmaceutics,  463, 170–176, 2014. IF = 3.650

2. Grumezescu, V., Socol, G., Grumezescu, A.M., Holban, A.M., Ficai, A., Trusca, R., Bleotu, C., Balaure, P.C., Cristescu, R., Chifiriuc, M.C. Functionalized antibiofilm thin coatings based on PLA-PVA microspheres loaded with usnic acid natural compounds fabricated by MAPLE. Applied Surface Science, 302, 262–267, 2014. IF = 2.711

3. Grumezescu, V.; Holban, A.M.; Iordache, F.; Socol, G.; Mogosanu, G.D.;  Grumezescu, A.M.; Ficai, A.; Vasile, B.S.; Trușcă, R.; Chifiriuc, C.M.; Maniu, H.  MAPLE fabricated magnetite@eugenol and (3-hidroxybutyric acid-co-3-hidroxyvaleric acid) – polyvinyl alcohol microspheres coated surfaces with anti-microbial properties. Applied Surface Science306, 16-22 2014. IF = 2.711

4. Chifiriuc, M.C., Grumezescu, A.M., Grumezescu, V., Bezirtzoglou, E., Lazar, V., Bolocan, A.Biomedical applications of natural polymers for drug delivery  (Review). Current Organic Chemistry, 18, 152-164, 2014. IF = 2.157

5. Grumezescu, V., Holban, A.M.,  Grumezescu, A.M., Socol, G., Ficai, A., Vasile, B.S., Trusca, R., Bleotu, C., Lazar, V., Chifiriuc, C.M., Mogosanu, G.D.  Usnic acid loaded biocompatible magnetic PLGA-PVA microspheres thin films fabricated by MAPLE with increased resistance to staphylococcal  colonization.  Biofabrication, 6, 035002, 2014.  IF = 4.289

6. Bertesteanu, S., Chifiriuc, M.C.,  Grumezescu, A.M., Printza Α.G., Thill, M.P., Grumezescu, V., Vlad, M., Lazar, V., Grigore, R. Biomedical Applications of Synthetic, Biodegradable Polymers for the Development of Anti-Infective Strategies.  Current Medicinal Chemistry, 21(29), 3383-90, 2014.  IF = 3.853

7. Grumezescu, A.M., Gestal, M.C., Holban, A.M., Grumezescu, V., Vasile, B.Ș., Mogoantă, L.,   Iordache, F., Bleotu, C., Mogoșanu, G.D. Biocompatible Fe3O4 increases the efficacy of amoxicillin delivery against Gram-positive and Gram-negative bacteria.  Molecules, 19, 5013-5027, 2014. IF = 2.416

8. Holban, A.M., Grumezescu, V.,  Grumezescu, A.M., Vasile B.Ș., Trușcă R., Cristescu, R., Socol, G., Iordache, F. Anti-microbial nanospheres thin coatings prepared by advanced pulsed laser technique.  Beilstein Journal of  Nanotechnology, 5, 872–880, 2014IF = 2.670

9. Anghel, A.G.; Grumezescu, A.M.; Chirea, M.; Grumezescu, V.; Socol, G.;  Iordache, F.; Oprea, A.E.; Anghel, I.; Holban, A.M. MAPLE fabricated Fe3O4@Cinnamomum verum antimicrobial surfaces for improved gastrostomy tubes. Molecules, 19, 8981-8994, 2014. IF = 2.416

10. Limban, C., Missir, A.V.,  Grumezescu, A.M., Oprea, A.E., Grumezescu, V., Vasile, B.Ș., Socol, G., Trușcă, R., Caproiu, M.T., Chifiriuc, M.C., Gălățeanu, B., Costache, M., Morușciag, L., Pîrcălăbioru, G., Nuță, D.C. Bioevaluation of novel anti-biofilm coatings based on PVP/Fe3O4 nanostructures and   2-((4-ethylphenoxy)methyl)-N-(arylcarbamothioyl)benzamides. Molecules, 19, 12011-12030, 2014. IF = 2.416

11. Holban A.M., Andronescu E., Grumezescu V., Socol G., Grumezescu A.M., Lazăr V., Chifiriuc M.C. Local delivery of tetracycline from gamma-aminobutiric acid-silica networks thin films for preventing microbial colonization. Biomaterials and Tissue Engineering Bulletin, 1(1-4), 2-9, 2014.

2013

1. Voicu, G., Grumezescu, V., Andronescu, E., Grumezescu, A.M., Ficai, A., Ghitulica, C.D., Gheorghe, I., Chifiriuc, M.C. Caprolactam-silica network, a strong potentiator of the antimicrobial activity of kanamycin against Gram-positive and Gram-negative bacterial strains. International Journal of Pharmaceutics, 446, 1–2,  63-69, 2013. IF = 3.785

2. Grumezescu, V., Chifiriuc, C.M., Holban, A.M., Stoica, P., Grumezescu, A.M., Voicu, G., Socol, G., Huang, K.S., Bleotu, C., Radulescu, R.  Antimicrobial And Biocompatibility Assay Of  Newly Fabricated Materials Based Copper Or Zinc Alginate And SiO2 Network. Digest Journal of Nanomaterials and Biostructures, 8, 2, 869 – 876, 2013. IF = 1.123

3. Grumezescu, A.M., Andronescu, E., Ficai, A., Grumezescu, V., Bleotu, C., Saviuc, C., Mihaiescu, D.E., Chifiriuc, C.M.  Biocompatible Magnetic Hollow Silica Microspheres for Drug Delivery. Current Organic Chemistry, 17, 1029-1033, 2013. IF = 2.537

4. Chifiriuc, M.C., Grumezescu, A.M., Saviuc, C., Hristu, R., Grumezescu, V., Bleotu, C., Stanciu, G., Mihaiescu, D.E., Andronescu, E., Lazar, V., Radulescu, R. Magnetic Nanoparticles for Controlling in vitro Fungal Biofilms. Current Organic Chemistry, 17, 1023-1028, 2013. IF = 2.537

5. Chifiriuc, M.C., Grumezescu, A.M., Andronescu, E., Ficai, A., Cotar, A.I., Grumezescu, V., Bezirtzoglou, E., Lazar, V., Radulescu, R. Water dispersible magnetite nanoparticles influence the efficacy of antibiotics against planktonic and biofilm embedded Enterococcus faecalis cells. Anaerobe, 22, 14-19, 2013. IF = 2.364

6. Grumezescu, A.M., Cotar, A.I., Andronescu, E., Ficai, A., Ghitulica, C.D., Grumezescu, V., Vasile, B.S., Chifiriuc, M.C. In vitro activity of the new water dispersible Fe3O4@Usnic Acid nanostructure against planktonic and sessile bacterial cells. Journal of Nanoparticle Research, 15, 1766, 2013. IF = 2.278

7. Grumezescu, A.M., Andronescu, E., Holban, A.M., Ficai, A., Ficai, D., Voicu, G., Grumezescu, V., Balaure, P.C., Chifiriuc, C.M. Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of different therapeutic agents.  International Journal of Pharmaceutics, 454, 233-240, 2013. IF = 3.785

8. Holban, A.M.; Grumezescu, A.M.; Andronescu, E.; Grumezescu, V.; Chifiriuc, C.M.; Rǎdulescu, R. Magnetite - Usnic acid nanostructured bioactive material with antimicrobial activity [Material nanostructurat bioactiv magnetitǎ - Acid usnic cu activitate antimicrobianǎ]. Revista Romana de Materiale/ Romanian Journal of Materials, 43 (4), 402-407, 2013. IF = 0.538

2012

1. Chifiriuc, C., Grumezescu, V., Grumezescu, A.M., Saviuc, C., Lazǎr, V., Andronescu, E. Hybrid magnetite nanoparticles/rosmarinus officinalis essential oil nanobiosystem with antibiofilm activity. Nanoscale Research Letters, 7, 209,  2012. IF = 2.524

2. Anghel, I., Grumezescu, V., Andronescu, E., Anghel, G.A., Grumezescu, A.M., Mihaiescu, D.E., Chifiriuc, M.C. Protective effect of magnetite nanoparticle/Salvia officinalis essential oil hybrid nanobiosystem against fungal colonization on the provox® voice section prosthesis. Digest Journal of Nanomaterials and Biostructures, 7 (3), 1205-1212, 2012. IF = 1.092

3. Anghel, I., Grumezescu, A.M., Andronescu, E., Anghel, A.G., Ficai, A., Saviuc, C., Grumezescu, V., Vasile, B.S., Chifiriuc, M.C. Magnetite nanoparticles for functionalized textile dressing to prevent fungal biofilms development. Nanoscale Research Letters, 7, 501, 2012. IF = 2.524

4. Grumezescu, A.M., Chifiriuc, M.C., Saviuc, C., Grumezescu, V., Hristu, R., Mihaiescu, D.E., Stanciu, G.A., Andronescu, E. Hybrid nanomaterial for stabilizing the antibiofilm activity of eugenia carryophyllata essential oil. IEEE Transactions on Nanobioscience, 11 (4), art. no. 6290401, pp. 360-365, 2012. IF = 1.286

 

Book chapters:

1. Negut, I., Grumezescu, V., Dorcioman, G. Chapter 6: Progress of nanoparticles research in cancer therapy and diagnosis. Nanostructures for Cancer Therapy, 159-176 Elsevier Inc., 2017. ISBN: 978-0-323-46144-3

2. Negut, I., Grumezescu, V., Dorcioman, G., Socol, G. Chapter 1: Microscale Drug Delivery Systems: Current Perspectives and Novel Approaches. Nano- and Microscale Drug Delivery Systems, 1-15, Elsevier Inc.,  2017.    ISBN: 978-0-323-52727-9

3. Negut, I., Grumezescu V., Sima, L.E., Axente, E., Recent Advances of Graphene Family Nanomaterials for Nanomedicine, Elsevier Inc.,  Accepted 2017

4. Chifiriuc, M.C., Fufă, O.M., Grumezescu, V., Andronescu, E., Grumezescu, A.M., Holban, A.M.  PLA and PLGA nanoarchitectonics for improving anti-infective drugs efficiency. Nanobiomaterials in Antimicrobial Therapy: Applications of Nanobiomaterials, Elsevier Inc., 451-482, 2016. ISBN: 978-032342887-3

5. Grumezescu V., Holban A.M., Barbu I., Popescu R.C., Oprea A.E., Lazar V., Grumezescu A.M., Chifiriuc M.C. Nanoarchitectonics used in antiinfective therapy. Book: Antibiotic Resistance Chapter 7, Elsevier Inc., 2016. ISBN: 978-0-12-803642-6

6. Grumezescu A.M., Holban A.M., Ficai A., Grumezescu V., Lazar V., Chifiriuc M.C. Biotechnology – Volume X: Nanobioctechnology, Nanosized Materials with Antibiofilm Activity, Studium Press LLC, Houston, USA, 2014. ISBN: 1-62699-025-5