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The
main goal of this project consists of the implementation of a new laser
technology for obtaining nanostructured biodegradable biocompatible coatings
with controlled porosity (polyethylene glycol –PEG, polyvinyl alcohol,
polylactic-co-glycolic acid) and their derivatives (esters, ethers,
ester-ethers, amines, etc) for pharmaceutical industry. Ob. 1. Study of physico-chemical
properties of powders of biocompatible polymers with controlled porosity (PEG,
PVA, PLGA) and their derivatives in view of getting MAPLE targets. Ob. 2. Obtaining biodegradable
biocompatible polymeric coatings onto substrates specific to the investigation
method. Ob. 3. Characterization of
MAPLE–deposited nanostructures by complementary investigation methods. Ob. 4 Tests of in vitro biocompatibility of used
biopolymers and MAPLE-deposited nanostructures behaviour under corosive action
of physiological fluids. Ob. 5 Performance of a sequence
of biocompatible polymers coatings with controlled porosity (PEG, PVA, and
PLGA) and their derivatives (esters, ethers, ester-ethers, amines, etc) which
will be evaluated from the quality and reproducibility point of view. The
sequence of presented objectives is in good correlation with the plan of
activities during this project. Also these are a good agreement between
established objectives and scientifical reports required during the project. The
project objectives are included by dealing with one of the most challenging
research topics in the CEEX Program and main pending and next European Contracts
(PC6 and PC7) priorities: nanosciences and nanotechnologies (i.e., MAPLE
technique for obtaining biocompatible polymers coatings with controlled
porosity and their derivatives; new materials: derivatives of PEG, PVA, PLGA;
targeted delivery of drug agents through nanostructured biopolymer coatings).
Investigations implied in this project will figure the scientifical base for
MAPLE implementation in the top pharmaceutical industry. |