The aim
of our research is the identification of innovative technologies for drug
delivery applications based on smart polymeric systems. The drug release from
polymeric matrices is externally controlled by means of magnetic and electrical
signals. Externally triggered on-demand drug release from such smart polymeric
systems can significantly improve the efficiency of the drug therapy since it
enables the delivery of the drug to a precise location at a precise
concentration and for a precise duration. In this pursuit, we propose three
synthesis approaches: i) submicron polymeric particles containing magnetic
nanoparticles ii) submicron particles based on electroactive polymers and, iii)
the combination of previous two solutions, magnetic nanoparticles embedded in
electroactive-based polymeric particles. The originality of the last two
approaches is the use of polymeric blends and (block) copolymers based on
electroactive and appropriate biodegradable polymers or monomers as matrix for
submicronic particles. The synthesis of magnetic and electrical-field-sensitive
polymeric nanoparticles will enhance the drug delivery effectiveness as a
response to the external fields because it combines both mechanisms of release.
Our smart polymeric systems will be tested in form of gels/suspensions or
coatings of nanoparticles.