The project “Fabrication of osteoinductive orthopedic implants with gradual 3D hierarchical structure” proposes a novel approach for the ossteointegration of permanent metallic prostheses by means of the surface alteration from morphological and biochemical point of view. The originality of the project consists in the development of implants with 3D hierarchical porous structure characterized by increased surface roughness and wettability, covered with soluble thin multilayer of biocatalytic composites. The resulting structures have the advantage of combining the benefits of deposited biomaterials and the mechanical strength of the metallic collector. The aim of our research is the manufacturing of permanent implants with biofunctional surface which are able to trigger certain healing phases typical for injured bone tissues. The implant fabricated as result of our research will induce complex chronological biological reactions which in the first stage will initiate a vasogenic and angiogenic response succeeded then by the migration and differentiation of osteoblasts and mesenchymal cells and accomplished with the formation of new bone tissue. Thus, the surface structure of the implant with appropriate topology and roughness will serve as framework for osteoconductivity, while further coating with biocomposites acts, in addition to osteoconductivity, as delivery vehicles for cytokines, such as bone morphogenetic proteins, insulin-like growth factors and transforming growth factors, vascular endothelial growth factor, etc. These growth factors will promote the migration and transformation of recruited precursor cells from the host producing new blood vessels and bone tissue, which finally will provide the osteoinduction. The proposed 3D structures for osteoinduction will mimic bone morphology, structure and function in order to optimize integration into surrounding tissue.