The surface functionalization of the implants represents an advanced development in implantology. Hydroxyapatite (HA) coatings for implants are the subject of recent researches pointing to the improvement of biointegration. 

This project aims to improve the efficiency of the public health system by studying and developing of Pulsed Laser Deposition protocols for the synthesis of biocompatible nanostructured layers of innovative materials (biological HA, simple or reinforced with various ions) onto metallic substrates (Ti and Ti alloys) for implantology. 

The synthesized nanostructures with controlled morphology, structure, thickness and adherence will be thoroughly studied by complex physical-chemical and mechanical investigations. During in-vitro specific bioactivity assays (Simulated Body Fluids), the physical-chemical modifications of the implant’s surface will be monitored as an effect of the interaction with the biological fluids. In-vitro cell cultures and antimicrobial tests will consist in the study of adhesion, proliferation and differentiation of cells and bacterial and fungal strains adhesion onto the studied materials, in order to quantify their biological response. 

The expected results refer to obtaining competitive biomimetic implants with increased functionality and biological efficiency as compared to the ones synthesized by plasma spraying, the single technique used nowadays for coating of medical implants.