surface functionalization of the implants represents an advanced
development in implantology. Hydroxyapatite (HA) coatings for implants
are the subject of recent researches pointing to the improvement of
project aims to improve the efficiency of the public health system by
studying and developing of Pulsed Laser Deposition protocols for the
synthesis of biocompatible nanostructured layers of innovative
materials (biological HA, simple or reinforced with various ions) onto
metallic substrates (Ti and Ti alloys) for implantology.
synthesized nanostructures with controlled morphology, structure,
thickness and adherence will be thoroughly studied by complex
physical-chemical and mechanical investigations. During in-vitro
specific bioactivity assays (Simulated Body Fluids), the
physical-chemical modifications of the implant’s surface will be
monitored as an effect of the interaction with the biological fluids.
In-vitro cell cultures and antimicrobial tests will consist in the
study of adhesion, proliferation and differentiation of cells and
bacterial and fungal strains adhesion onto the studied materials, in
order to quantify their biological response.
expected results refer to obtaining competitive biomimetic implants
with increased functionality and biological efficiency as compared to
the ones synthesized by plasma spraying, the single technique used
nowadays for coating of medical implants.