Miniaturized bio-platform for simultaneous melanoma combination therapy and tumorigenicity screening - MiniBioLab

Project number 131PED/2017
This contract is financed by
Romanian National Authority for Scientific Research,
CNCS-UEFISCDI
Project code : PN-III-P2-2.1-PED-2016-1628

https://mobirise.com/

Research Team

Coordinator - INFLPR

Partner  
Institute of Biochemistry - Romanian Academy

Coordinator : Dr. Gabriela Chiritoiu
Dr. Cristian Munteanu

Objectives

The goal of this project proposal is to design, develop and test the performances of a miniaturized bio-platform that will simultaneously address two objectives: 

    i) the synergistic co-targeting of melanoma cells by a precise combinatorial mixture of signaling path inhibitors (BRAFi, NRASi) and epigenetic modulators (HDACi); and

    ii) the evaluation of melanoma cells tumorigenicity guided by the geometric features of the patterns assembled on solid substrates.


Dissemination

Book chapters:

        1 “Recent Advances of Graphene Family Nanomaterials for Nanomedicine” Chapter, in “Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach” 1st Edition, Eds. Alexandru Grumezescu, Elsevier, ISBN 9780128136911 (2018). Irina NEGUT, Valentina GRUMEZESCU, Livia SIMA* and Emanuel AXENTE*


         2. “Combinatorial laser synthesis of biomaterial thin films: selection and processing for medical applications” Chapter, in “Advances in the Application of Lasers in Materials Science”, Eds. M. Dinescu. D.B. Geohegan, A. Miotello and P.M. Ossi, Springer (2018). Emanuel Axente, Carmen Ristoscu, Adriana Bigi, Felix Sima, and Ion N. Mihailescu


Articles:

        1. „Combinatorial laser synthesis of compositional library thin films for screening of molecular-targeted agents in melanoma” To be submitted to ACS Combinatorial Science (2018) L.E. Sima,* I. Negut, V. Grumezescu, S. Iosub, G. Chiritoiu, C. Hapenciuc, F. Sima, and E. Axente,*


         2. „Functionalized graphene oxide nanomaterials: in vitro cytotoxicity and BRAF inhibition in melanoma cells” FEBS JOURNAL Volume: 284 Special Issue: SI Supplement: 1 Pages: 328-328 Meeting Abstract: P.5.2-018 Published: SEP 2017 V. Grumezescu, I. Negut, S. Iosub, G. Chiritoiu, C. Hapenciuc, F. Sima, L.E. Sima,* and E. Axente,*


National and International Conferences:  

        1. “Porous carbon thin films by Matrix-Assisted Pulsed Laser Evaporation from environmental friendly organic precursors” Poster presented at Symposium X : New frontiers in laser interaction: from hard coatings to smart materials of the E-MRS 2017 Spring Meeting, May 22-26, 2017, Strasbourg (France). E. Axente, M. Sopronyi, C.M. Ghimbeu, F. Sima


       2. “MAPLE synthesis of Graphene Oxide composites for nanomedicine” Poster presented at IONS Balvanyos Conference 2017, International OSA Network of Students, 25-28 July 2017. I. Negut, V. Grumezescu, S. Iosub, C. Hapenciuc, F. Sima, G. Chiritoiu, L.E. Sima* and E. Axente*


       3. „Functionalized graphene oxide nanomaterials: in vitro cytotoxicity and BRAF inhibition in melanoma cells” Conference: 42nd Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back Location: Jerusalem, ISRAEL Date: SEP 10-14, 2017 V. Grumezescu, I. Negut, S. Iosub, G. Chiritoiu, C. Hapenciuc, F. Sima, L.E. Sima,* and E. Axente,*


Seminars:

       1. „MiniBioLab Project: Current status and further perspectives”, Photonic Investigations Laboratory, CETAL Department, INFLPR, September 15, 2017. Emanuel Axente