This contract is financed by Romanian National Authority for Scientific Research, CNCS-UEFISCDI,
project no. PN-II-RU-TE-2014-4-0396
The production of biodegradable Mg-based metal implants is a challenging topic. There are still several involved processes that are not fully understood. The investigation of these phenomena will enable the development of a new generation of biomedical implants. One of the most effective ways to protect metal implants from corrosive media is to coat the base materials with innovative bioactive biomaterials which are expected to promote synergic interactions between implant and tissue. The innovative solution proposed in this project is to obtain by pulsed laser technologies, thin coatings with different characteristics. Our approach will permit a shortening of patients healing time and provide a solution for the long-term modification of biodegradable metallic implant-like surfaces.
Objectives:
1. Development of advanced pulsed laser technologies suitable for thin films deposition;
2. Selecting the optimal composition with highest corrosive action and efficiency antimicrobial activity.
3. Further research on MAPLE depositions on the selected compositions in objective 2.
4. Development of technologies for anticorrosive and antimicrobial coatings on large surfaces to be used on Mg/Mg alloys MIs.
Expected Results :
1.Development of a new generation of biodegradable MIs based on Mg/Mg alloys which is expected not to be unaffected by dysfunctions encountered in the research reported in recent studies.
1. University “Politehnică” Bucharest , Faculty of Applied Chemistry and Material Science - ROMANIA;
2. Center for Advanced Laser Technologies (CETAL), Biological Testing Laboratory - ROMANIA;
3. University “Transilvania” Brașov - ROMANIA;
4. University of Bucharest, Faculty of Biology - ROMANIA;
5. University Aveiro, Department of Materials and Ceramics Engineering, Aveiro - PORTUGALIA.
Paper published in ISI journals:
1) „Bioactive glass thin films synthesized by advanced pulsed laser techniques” N. Mihăilescu, George E. Stan, C. Ristoscu, M. Sopronyi și Ion N. Mihăilescu, Journal of Physics: Conference Series 764 (2016) 012020 doi:10.1088/1742-6596/764/1/012020;
2) „Functionalized Antimicrobial Composite Thin Films Printing for Stainless Steel Implant Coatings”, Laura Floroian , Carmen Ristoscu, Natalia Mihailescu, Irina Negut, Mihaela Badea, Doru Ursutiu, Mariana Carmen Chifiriuc, Iuliana Urzica, Hussien Mohammed Dyia, Coralia Bleotu si Ion N. Mihailescu, Molecules 2016, 21, 740; doi:10.3390/molecules21060740;
3) „Antimicrobial thin films based on ayurvedic plants extracts embedded in a bioactive glass matrix”, L. Floroian, C. Ristoscu, N. Mihailescu, I. Negut, M. Badea, M. Gilca, G. Candiani, N. Pastori, M. Moscatelli, R. Chiesa, si I.N. Mihailescu, Applied Surface Science, Volume 417, 30 September 2017, Pages 224-233;
4) „Comparative physical, chemical and biological assessment of simple and titanium-doped ovine dentine-derived hydroxyapatite coatings fabricated by pulsed laser deposition”, L. Duta, N. Mihailescu, A.C. Popescu, C.R. Luculescu, I.N. Mihailescu, G. Çetin, O. Gunduz, F.N. Oktar, A.C. Popa, A. Kuncser, C. Besleaga, G.E. Stan, Applied Surface Science, Volume 413, 15 August 2017, Pages 129-139
5) „In vitro behavior of human mesenchymal stem cells on poly(Nisopropylacrylamide) based biointerfaces obtained by Matrix Assisted Pulsed Laser Evaporation”, Madalina Icriverzi, Laurentiu Rusen, Valentina Dinca, Livia Elena Sima, Antoniu Modovan, Simona Brajnicov, Anca Bonciu, Natalia Mihailescu, Maria Dinescu, Anisoara Cimpean and Anca Roseanu, under review Jurnalul Applied Surface Science;
6) „Compositional gradient biopolymer thin film assemblies synthesized by Combinatorial Matrix Assisted Pulsed Laser Evaporation (C-MAPLE)”, Natalia Mihailescu, Merve Erginer Haskoylu, Carmen Ristoscu, Müge Sennaroglu Bostan, Emanuel Axente, Mihai Sopronyi, Mehmet Eroğlu, Mariana Carmen Chifiriuc, Cosmin Catalin Mustaciosu, EbruToksoy Oner, Ion N. Mihailescu, under review - Biofabrication;
7) „Corrosion studies of Mg/Mg –based alloys as biodegradable metallic materials”, Natalia Mihailescu, A. Ficai, I. Negut, Roxana Truscă, Dragos Gudovan, Laura Floroian, and Ion N. Mihailescu, under review - Jurnalul Corrosion Science;
8) „Nanostructured bioactive glass coatings synthesized by pulsed laser deposition onto biodegradable metallic implants”, Natalia Mihailescu, M. Sopronyi, A. Ficai, Laura Floroian, Irina Negut, Carmen Ristoscu, G. Stan, José M.F. Ferreira, and Ion N. Mihailescu, under review - Jurnalul Biofabrication.
Book chapter:
1) „Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques”, Emanuel Axente, Felix Sima, Carmen Ristoscu, Natalia Mihailescu and Ion N. Mihailescu, Ed. InTech, Chapter 4 in Recent Advances in Biopolymers, pag 74-104, 2016.
International Conferences:
1) Best-Poster la Conferința INERA – 2016, Vapor Phase Technologies for metal oxide and carbon nanostructures, 5 – 9 July 2016, Velingrad, Bulgaria, „Nanostructured bioactive glass thin films synthesized by pulsed laser deposition onto biodegradable metallic implants”, Natalia Mihăilescu, G.E. Stan, Carmen Ristoscu, M. Sopronyi, și Ion N. Mihailescu.
2) Poster prezentat la Conferinta ICPEPA-10, 10th International Conference on Photoexcited Processes and Applications, August 29 – September 2, 2016, Brasov, Romania, „Nanostructured bioactive glass thin films synthesized by pulsed laser deposition onto biodegradable metallic implants”, Natalia Mihailescu, A. Ficai, M. Sopronyi, Laura Floroian, G.E. Stan, Irina Negut, C. Hapenciuc, Carmen Ristoscu, F. Sima, C.N. Mihailescu, J.M.F. Ferreira and Ion N. Mihailescu.
3) Oral presentation at EMRS Fall Meeting – 2017, 17-21.9.2017, at Faculty of Materials Science and Engineering Warsaw University of Technology. Title : „Biocompatibility and antimicrobial improvement of metallic implants by C-MAPLE”, presented by Mihai Sopronyi. M. Sopronyi, N.Mihailescu, A. Ficai, C. Ristoscu,C.N. Mihailescu, L.Floroian, M. C. Chifiriuc, I.Negut, I.N. Mihailescu
Excimer KrF (248 nm) Coherent COMPex Pro 205 laser
Atomic Force Microscope (AFM) – cofinanced from TE187 (Dr. F. SIMA) and
